{"product_id":"2940165807992","title":"A Simple Guide to Pick Disease, Diagnosis, Treatment and Related Conditions","description":"\u003cp\u003eThis book describes Pick Disease, Diagnosis and Treatment and Related Diseases\u003c\/p\u003e\u003cp\u003ePick disease (PD) is a rare brain disorder that produces progressive and irreversible dementia.\u003c\/p\u003e\u003cp\u003eThis disease is featured by behavioral changes and language deficits with frontal and temporal cortical degeneration.\u003c\/p\u003e\u003cp\u003eIt is a heterogeneous disorder featuring a range of overlapping medical, genetic, and pathological causes leading to a single phenotypic expression of disease.\u003c\/p\u003e\u003cp\u003eIt is often a form of frontotemporal dementia and often happens in pre-senile patients.\u003c\/p\u003e\u003cp\u003eIf the person has dementia, the brain does not function normally.\u003c\/p\u003e\u003cp\u003eAs a result, the person may have difficulty with behavior, language, judgment, and memory.\u003c\/p\u003e\u003cp\u003eLike patients with other types of dementia, the person may have drastic personality changes.\u003c\/p\u003e\u003cp\u003eWhile Alzheimer’s disease can involve many different parts of the brain, Pick disease only affects the frontal and temporal lobes.\u003c\/p\u003e\u003cp\u003eThe brain’s frontal lobe regulates important aspects of everyday life such as planning, judgment, emotional control, behavior, inhibition, executive function, and multitasking.\u003c\/p\u003e\u003cp\u003eThe temporal lobe mainly involves language, together with emotional response and behavior.\u003c\/p\u003e\u003cp\u003eFrontotemporal dementia is divided into:\u003cbr\u003eBehavioral variant (bvFTD) and\u003cbr\u003ePrimary progressive aphasia (PPA) subtypes.\u003c\/p\u003e\u003cp\u003ePPA is further categorized as:\u003cbr\u003eNon-fluent\/agrammatic variant (nfvPPA),\u003cbr\u003eSemantic variant (svPPA), and\u003cbr\u003eLogopenic aphasia.\u003cbr\u003eMotor neuron disease (FTD-MND),\u003cbr\u003eProgressive supranuclear palsy (PSP-S), and\u003cbr\u003eCorticobasal syndrome (CBS)\u003c\/p\u003e\u003cp\u003ePick disease (a form of Frontotemporal dementia) is produced by abnormal quantities or types of nerve cell proteins or tau.\u003c\/p\u003e\u003cp\u003eThese proteins are present in all of the nerve cells.\u003c\/p\u003e\u003cp\u003eTau, transactive response DNA binding protein 43 (TDP-43), and RNA-binding protein fused in sarcoma (FUS) have been determined as the main proteins responsible for Pick disease.\u003c\/p\u003e\u003cp\u003eThese proteins often accumulate into spherical clumps, termed Pick bodies.\u003c\/p\u003e\u003cp\u003eWhen they collect in nerve cells of the brain’s frontal and temporal lobe, they cause the cells to die.\u003c\/p\u003e\u003cp\u003eThis induces the brain tissue to atrophy (shrink), leading to the symptoms of dementia.\u003c\/p\u003e\u003cp\u003eDoctors do no know what causes these abnormal proteins to develop.\u003c\/p\u003e\u003cp\u003eBehavior and personality alterations are the most significant early symptoms in Pick’s disease.\u003c\/p\u003e\u003cp\u003eBehavioral and emotional symptoms may be felt as:\u003cbr\u003eAbrupt mood changes\u003cbr\u003eCompulsive or inappropriate behavior\u003cbr\u003eDepression-like symptoms, such as no interest in daily activities\u003cbr\u003eWithdrawal from social interaction\u003cbr\u003eDifficulty keeping a job\u003cbr\u003ePoor social skills\u003cbr\u003ePoor personal hygiene\u003cbr\u003eRepetitive behavior\u003c\/p\u003e\u003cp\u003eLanguage and neurological changes may be felt as:\u003cbr\u003eReduced writing or reading skills\u003cbr\u003eEchoing, or repeating what has been said\u003cbr\u003eInability to speak, difficulty speaking, or trouble understanding speech\u003cbr\u003eShrinking vocabulary\u003cbr\u003eAccelerated memory loss\u003cbr\u003ePhysical weakness\u003c\/p\u003e\u003cp\u003ePick disease can also happen at an earlier age (as young as 20 years old) than Alzheimer’s\u003c\/p\u003e\u003cp\u003eStandard, structural magnetic resonance imaging (MRI), and computed tomography (CT) scans can reveal typical atrophy of frontal and temporal lobe grey matter.\u003c\/p\u003e\u003cp\u003eThere is no known cure or treatment that can successfully reduce the progression of FTD.\u003c\/p\u003e\u003cp\u003eThe doctor can provide antidepressant and antipsychotic medicines to treat emotional and behavioral changes.\u003c\/p\u003e\u003cp\u003ePhysical therapy and exercise can reduce cognitive deterioration while speech therapy may relieve language deficits in patients with the primary progressive aphasia variants\u003c\/p\u003e\u003cp\u003eTABLE OF CONTENT\u003cbr\u003eIntroduction\u003cbr\u003eChapter 1 Pick Disease\u003cbr\u003eChapter 2 Causes\u003cbr\u003eChapter 3 Symptoms\u003cbr\u003eChapter 4 Diagnosis\u003cbr\u003eChapter 5 Treatment\u003cbr\u003eChapter 6 Prognosis\u003cbr\u003eChapter 7 Dementia\u003cbr\u003eChapter 8 Alzheimer’s Disease\u003cbr\u003eEpilogue\u003c\/p\u003e","brand":"Kenneth Kee","offers":[{"title":"Default Title","offer_id":46461218324721,"sku":"2940165807992","price":2.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/5433\/7265\/files\/2940165807992_p0.jpg?v=1765692408","url":"https:\/\/shop.barnesandnoble.com\/products\/2940165807992","provider":"Barnes \u0026 Noble","version":"1.0","type":"link"}