{"product_id":"9781475773422","title":"Taurine 4: Taurine and Excitable Tissues","description":"Mihondria from mammalian tissues possess an elaborate system for 2+ 2+ transporting Ca across their inner membrane which consists of Ca import, 2+ via the Ca uniporter, in response to the mihondrial membrane 2+ + potential—? and of Ca release by an antiport system in exchange for H + 9,23 or Na (see Fig. l) . Because the uniporter is dependent upon the external 2+ 2+ 2+ 2+ Ca concentration ([Ca ]), mihondria accumulate Ca until the [Ca ] o o 2+ decreases to the level at which the uniporter activity balances the Ca efflux. 2+ The [Ca ] at which the uniporter and efflux activities are equal is defined o the “setpoint” andcorresponds to values between 0.3-3µM. 2+ Figure 1. The Ca transport system of the inner membrane of mammalian mihondria. U, + 2+ + + uniporter. I, Na -independent efflux mechanism or Ca \/2H exchanger. D, Na -dependent 2+ + efflux mechanism or Ca \/2Na exchanger. PTP, permeability transition pore. FP, 11 flavoprotein.—? membrane potential.— pH gradient. Adapted from .","brand":"Springer US","offers":[{"title":"Default Title","offer_id":46361691390193,"sku":"9781475773422","price":219.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/5433\/7265\/files\/9781475773422_p0.jpg?v=1764935384","url":"https:\/\/shop.barnesandnoble.com\/products\/9781475773422","provider":"Barnes \u0026 Noble","version":"1.0","type":"link"}