Protein Engineering of of Carcinoembryonic Antigen and their receptors: Protein Engineering

Carcinoembryonic antigen (CEA), one of the onco-fetal proteins, is a cell surface glycoprotein, with a high molecular mass of 150-300 kDa. It is normally expressed in the early embryonic development and tends to disappear with the onset of differentiation of fetal tissue into adult ones. CEA has been studied extensively in ovarian cancer and has been reported to be elevated in 30-65% of epithelial tumors, mainly in patients with advanced stage disease. This antigen has been shown not to correlate well with status of disease.