Translational Epigenomic Medicine Innovation: Gene & Environment Interaction Disease Causation

Medicine remains an inexact science, since the only known diagnosis is mortality, but when and how is not very fully understood, indicative of mutualistic, collaborative, transdisciplinary, symbiotic, translational, team science and dynamic initiatives in the understanding of disease risk determinants, morbidity, therapeutics, prognosis, survival and mortality; as well as aberrant epigenomic modulation in disease occurrence. Since disease process is significantly driven by environment and not genes as DNA sequence (genomics), but gene and environment interaction, as epigenomic modulations in disease etiology, therapeutics, prognosis and survival, there is a need to understand specific environments associated with DNA, and the application of such understanding in disease prevention and control, as well as therapeutics.
This novel clinical medicine initiatives involves the application of patient's environment (exogenous, endogenous, air pollutants, toxic waste, water quality, stress, discrimination, tobacco, vape, alcohol, health insurance coverage, discrimination, nutrition, sleep pattern, physical activities, etc) in disease and health outcomes improvement. DNA methylation and histone modification remain essential in normal human being anatomic and physiologic process. Nutritional imbalance such as high lipid, cholesterol, triglycerides, fat and sodium diets could induce DNA damage, hence aberrant epigenomic modulations in disease causation such as HTn, CVDs, CVAs and malignant neoplasm.